Does SIRT-1 Mediate Calorie Restriction and Prolong Life?

How does calorie restriction work?

For almost 70 years, calorie restriction has been known to extend life span. Despite the extensive physiological characterization of this dietary regimen, the molecular basis for the slowing in aging remains unsolved. Recent findings have pinpointed a few molecular pathways that appear to regulate the aging process. In this review, we propose a molecular model for how calorie restriction works ...

Calorie Restriction, Longevity and Cognitive Function

Calorie restriction and aging: a life-history analysis.

The disposable soma theory suggests that aging occurs because natural selection favors a strategy in which fewer resources are invested in somatic maintenance than are necessary for indefinite survival. However, laboratory rodents on calorie-restricted diets have extended life spans and retarded aging. One hypothesis is that this is an adaptive response involving a shift of resources during sho...

Calorie Restriction

Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...

Calorie Restriction Extends Life Span— But Which Calories?

E vidence that calorie restriction (CR) retards aging and extends median and maximal life span was fi rst described in the 1930s by McCay et al. [1]. Since then, similar observations have been made in a variety of species including rodents, fi sh, fruit fl ies, worms, and yeast [2]—and although they are not yet defi nitive, results from ongoing longevity studies in monkeys suggest that CR will ...